Thiazolidinediones: the Forgotten Diabetes Medications
نویسندگان
چکیده
منابع مشابه
Type 2 diabetes, thiazolidinediones, and cardiovascular risk.
Type 2 diabetes is a common disorder with an increased risk of macrovascular complications. Achieving adequate glycaemic control is an important aim of therapy. Thiazolidinediones, or glitazones, have been used for the treatment of diabetes for a decade. Rosiglitazone and pioglitazone are currently available, however recent concerns around cardiovascular safety have led to restrictions on their...
متن کاملHeart failure, diabetes and the thiazolidinediones: an unfolding story
Samy I McFarlane1† & Fadi A El-Atat2 †Author for correspondence 1†SUNY-Downstate and Kings County Hospital Centers, Division of Endocrinology, Diabetes and Hypertension, 450 Clarkson Avenue, Box 50, Brooklyn, NY, 11203, USA Tel: +1 718 270 3711 Fax: +1 718 270 6358 2SUNY-Downstate and Kings County Hospital Centers, Division of Cardiovascular Medicine, 450 Clarkson Avenue, Box 50 Brooklyn, NY, 1...
متن کاملThe impact of diabetes and diabetes medications on bone health.
Patients with type 2 diabetes mellitus (T2DM) have an increased risk of fragility fractures despite increased body weight and normal or higher bone mineral density. The mechanisms by which T2DM increases skeletal fragility are unclear. It is likely that a combination of factors, including a greater risk of falling, regional osteopenia, and impaired bone quality, contributes to the increased fra...
متن کاملEffectiveness and side effects of thiazolidinediones for type 2 diabetes.
OBJECTIVE To assess effectiveness and side effects of thiazolidinediones (TZDs) as adjunctive therapy in suboptimally controlled patients with type 2 diabetes. DESIGN AND SETTING Review of a prospectively recorded database at the Royal Melbourne Hospital diabetes clinic. PARTICIPANTS 203 patients with type 2 diabetes who received pioglitazone or rosiglitazone between 1 May 2000 and 31 Octob...
متن کامل[Diabetes mellitus, thiazolidinediones and fractures: an unfinished story].
The association of diabetes mellitus with increased fracture risk is well established, and is observed in both diabetes type 1 and type 2, due to multiple causes. Evidence from rodents suggests that thiazolidinediones (TZD), by activation of PPAR-gamma, cause increased bone marrow adiposity, with decreased osteoblastogenesis resulting in bone loss. Initial studies in humans evidence higher frac...
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ژورنال
عنوان ژورنال: Current Diabetes Reports
سال: 2019
ISSN: 1534-4827,1539-0829
DOI: 10.1007/s11892-019-1270-y